Please login first
Susan A. Charman  - - - 
Top co-authors See all
Julie A. Simpson

247 shared publications

27 Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Victoria, Australia

Darren J. Creek

117 shared publications

Drug Delivery Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University (Parkville Campus), 381 Royal Parade, Parkville, Victoria 3052, Australia

Margaret A. Phillips

117 shared publications

Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, Texas 75390, United States

James M. McCaw

104 shared publications

School of Mathematics and Statistics, The University of Melbourne, Parkville, Victoria, Australia

Kevin D Read

68 shared publications

Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dow Street, Dundee DDI 5EH, U.K.

163
Publications
0
Reads
0
Downloads
399
Citations
Publication Record
Distribution of Articles published per year 
(1993 - 2018)
Total number of journals
published in
 
29
 
Publications See all
Article 0 Reads 0 Citations Application of PBPK modeling to evaluate pharmacokinetic drug-drug interactions during the development of new antimalari... Nada Abla, Lisa Almond, Maurice Dickins, Nathalie Gobeau, Su... Published: 01 January 2019
Drug Metabolism and Pharmacokinetics, doi: 10.1016/j.dmpk.2018.09.234
DOI See at publisher website
Article 0 Reads 0 Citations Evaluation of 4-Amino 2-Anilinoquinazolines against Plasmodium and Other Apicomplexan Parasites In Vitro and in a P. fal... Paul R. Gilson, William Nguyen, William A. Poole, Jose E. Te... Published: 17 December 2018
Antimicrobial Agents and Chemotherapy, doi: 10.1128/aac.01804-18
DOI See at publisher website
Article 0 Reads 0 Citations SAR of a new antischistosomal urea carboxylic acid Jianbo Wu, Chunkai Wang, Cécile Häberli, Karen L. White, Dav... Published: 01 December 2018
Bioorganic & Medicinal Chemistry Letters, doi: 10.1016/j.bmcl.2018.10.039
DOI See at publisher website
Article 0 Reads 0 Citations Inhibition of Cytomegalovirus Replication with Extended-Half-Life Synthetic Ozonides Yiping Wang, Rupkatha Mukhopadhyay, Sujayita Roy, Arun Kapoo... Published: 29 October 2018
Antimicrobial Agents and Chemotherapy, doi: 10.1128/aac.01735-18
DOI See at publisher website
Article 1 Read 0 Citations Erratum for Brunschwig et al., “UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for... Christel Brunschwig, Nina Lawrence, Dale Taylor, Efrem Abay,... Published: 24 October 2018
Antimicrobial Agents and Chemotherapy, doi: 10.1128/aac.01941-18
DOI See at publisher website PubMed View at PubMed
Article 0 Reads 0 Citations Using Human Plasma as an Assay Medium in Caco-2 Studies Improves Mass Balance for Lipophilic Compounds Kasiram Katneni, Thao Pham, Jessica Saunders, Gong Chen, Rah... Published: 17 September 2018
Pharmaceutical Research, doi: 10.1007/s11095-018-2493-3
DOI See at publisher website PubMed View at PubMed ABS Show/hide abstract
To examine the utility of human plasma as an assay medium in Caco-2 permeability studies to overcome poor mass balance and inadequate sink conditions frequently encountered with lipophilic compounds. Caco-2 permeability was assessed for reference compounds with known transport mechanisms using either pH 7.4 buffer or human plasma as the assay medium in both the apical and basolateral chambers. When using plasma, Papp values were corrected for the unbound fraction in the donor chamber. The utility of the approach was assessed by measuring the permeability of selected antimalarial compounds using the two assay media. Caco-2 cell monolayer integrity and P-gp transporter function were unaffected by the presence of human plasma in the donor and acceptor chambers. For many of the reference compounds having good mass balance with buffer as the medium, higher Papp values were observed with plasma, likely due to improved acceptor sink conditions. The lipophilic antimalarial compounds exhibited low mass balance with buffer, however the use of plasma markedly improved mass balance allowing the determination of more reliable Papp values. The results support the utility of human plasma as an alternate Caco-2 assay medium to improve mass balance and permeability measurements for lipophilic compounds. The online version of this article (10.1007/s11095-018-2493-3) contains supplementary material, which is available to authorized users.
Top