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Sajid A. Khan  - - - 
Top co-authors
Ronald R. Salem

37 shared publications

Departments of Surgery, Yale School of Medicine, New Haven, USA

Gabriella Grisotti

1 shared publications

Rebecca Zhu

1 shared publications

8
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Publication Record
Distribution of Articles published per year 
(2015 - 2018)
Total number of journals
published in
 
7
 
Publications See all
Article 0 Reads 0 Citations Defining Early-Onset Colon and Rectal Cancers Daniel Jacobs, Rebecca Zhu, Jiajun Luo, Gabriella Grisotti, ... Published: 06 November 2018
Frontiers in Oncology, doi: 10.3389/fonc.2018.00504
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Background: Colorectal cancer (CRC) incidence is rising in the young, yet the age of those affected is not clearly defined. In this study, we identify such cohorts and define clinicopathological features of early-onset colon and rectal cancers. Methods: The Surveillance, Epidemiology and End Results Program (SEER) database was queried to compare clinicopathological characteristics of colon and rectal cancers diagnosed during 1973–1995 with those diagnosed during 1995–2014. Results: We identified 430,886 patients with colon and rectal cancers. From 1973–1995 to 1995–2014, colon cancer incidence increased in patients aged 20–44 years, while rectal cancer incidence increased in patients aged ≤54 years. The percent change of cancer incidence was greatest for rectal cancer with a 41.5% (95% confidence interval (CI): 37.4–45.8%) increase compared to a 9.8% (CI: 6.2–13.6%) increase in colon cancer. Colon cancer has increased in tumors located in ascending, sigmoid, and rectosigmoid locations. Adenocarcinoma histology has increased in both colon and rectal cancers (P < 0.01), but mucinous and signet ring cell subtypes have not increased (P = 0.13 and 0.08, respectively). Incidence increases were race-specific, with rectal cancer seeing similar rises in white (38.4%, CI: 33.8–43.1%) and black populations (38.0%, CI: 26.2–51.2%), while colon cancer as a whole saw a rise in white (11.5%, CI: 7.2–15.9%) but not black populations (−6.8%, CI: −14.6–1.9%). Conclusions: Our study underscores the existence of key differences between early-onset colon (20–44 years) and rectal cancers (≤54 years) and provides evidence-based inclusion criteria for future investigations. We recommend that future research of CRC in the young should avoid investigating these cases as a single entity.
Article 0 Reads 0 Citations Clinical impact of underutilization of adjuvant therapy in node positive gastric adenocarcinoma Rebecca Zhu, Fangfang Liu, Gabriella Grisotti, Javier Perez-... Published: 01 June 2018
Journal of Gastrointestinal Oncology, doi: 10.21037/jgo.2018.03.05
DOI See at publisher website
Article 1 Read 1 Citation Distinctive features of gastrointestinal stromal tumors arising from the colon and rectum Rebecca Zhu, Fangfang Liu, Gabriella Grisotti, Javier Perez-... Published: 01 April 2018
Journal of Gastrointestinal Oncology, doi: 10.21037/jgo.2017.11.12
DOI See at publisher website
Article 0 Reads 1 Citation Hyperparathyroidism-Jaw Tumor Syndrome Associated With Large-Scale 1q31 Deletion Jill C. Rubinstein, Sachin K. Majumdar, William Laskin, Fran... Published: 25 May 2017
Journal of the Endocrine Society, doi: 10.1210/js.2016-1089
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Hyperparathyroidism-jaw tumor syndrome (HPT-JT) is a rare autosomal dominant cause of familial hyperparathyroidism associated with benign, ossifying fibromas of the maxillofacial bones and increased risk of parathyroid carcinoma. The putative tumor suppressor gene CDC73 has been implicated in the syndrome, with a multitude of inactivating mutations identified; however, HPT-JT due to large-scale deletion of the chromosomal region containing the gene is exceedingly rare, and the clinical significance of this variant remains unclear. We report the case of a 32-year-old woman with a history of mandibular ossifying fibroma who presented with primary hyperparathyroidism and was found to harbor a large-scale, germline deletion on chromosome 1q31, including the CDC73 locus. HPT-JT is associated with loss of function of the putative tumor suppressor gene CDC73. Over 100 mutations and small insertions/deletions have been identified within the gene, the majority of which result in premature truncation of the parafibromin protein product. We report a case of HPT-JT associated with a large chromosomal deletion (4.1 Mb) encompassing the CDC73 gene locus. In the future, molecular testing in this autosomal dominant disorder should use techniques that allow for the detection of large-scale deletions in addition to the more commonly observed mutations and smaller-scale copy number alterations. Further investigation is needed to determine whether HPT-JT associated with a large-scale deletion carries increased risk of malignancy relative to the more common truncating mutations and what the implications are for genetic counseling.
Article 0 Reads 5 Citations EGFR Gene Amplification and KRAS Mutation Predict Response to Combination Targeted Therapy in Metastatic Colorectal Canc... Zhaoshi Zeng, Jinru Shia, Sajid A. Khan, Philip B. Paty Published: 26 December 2016
Pathology & Oncology Research, doi: 10.1007/s12253-016-0166-2
DOI See at publisher website PubMed View at PubMed
Article 0 Reads 4 Citations Colorectal cancer in the very young: a comparative study of tumor markers, pathology and survival in early onset and adu... Sajid A. Khan, Melinda Morris, Kamran Idrees, Mark I. Gimbel... Published: 01 November 2016
Journal of Pediatric Surgery, doi: 10.1016/j.jpedsurg.2016.07.015
DOI See at publisher website PubMed View at PubMed
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