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Yawei Zhang      
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Yawei Zhang published an article in February 2019.
Top co-authors See all
Peter Boyle

505 shared publications

International Prevention Research Institute, Lyon, France

Stephen J. Chanock

447 shared publications

Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

Alan R. Shuldiner

444 shared publications

University of Maryland School of Medicine Department of Medicine, Baltimore, MD, USA

Braxton D. Mitchell

444 shared publications

Program in Personalized and Genomic Medicine, and Department of Medicine, Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, MD

Shuangge Ma

300 shared publications

Department of Biostatistics, Yale University, New Haven, CT 06520, USA

61
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427
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Publication Record
Distribution of Articles published per year 
(2005 - 2019)
Total number of journals
published in
 
33
 
Publications See all
Article 0 Reads 0 Citations Total cholesterol to high-density lipoprotein cholesterol ratio is a significant predictor of nonalcoholic fatty liver: ... Xiao Yu Ren, Dian Shi, Jiao Ding, Zhi Yuan Cheng, Hai Yan Li... Published: 11 February 2019
Lipids in Health and Disease, doi: 10.1186/s12944-019-0984-9
DOI See at publisher website PubMed View at PubMed ABS Show/hide abstract
Some studies found out that TC/HDL-C ratio is a predictor of Cardiovascular disease (CVD) and Nonalcoholic fatty liver (NAFLD) is related to CVD. And some researches have already studied that Apolipoprotein B to Apolipoprotein A1 ratio (ApoB/ApoA1) and Triglyceride to High-density lipoprotein cholesterol ratio (TG/HDL-C) were both related with CVD and NAFLD, but few studied the association between TC/HDL-C ratio and NAFLD. So, we suspected the ratio was also related to NAFLD. The research aims to study the predictive value of TC/HDL-C to NAFLD and to help the early detection of NAFLD. Based on the Jinchang Cohort, the study contained 32,121 participants. We assessed the incidence of NAFLD by the quartiles of TC, HDL-C and TC/HDL-C. Then, the does-response relationship between these indicators and the risk of NAFLD was obtained. Finally, the receiver operator characteristic curve (ROC) was applied to decide the predictive value of TC/HDL-C. Among the study participants, the cumulative incidence of NAFLD was 6.30% and the rate of dyslipidemia was 40.37%. The biochemical indicators of NAFLD had a difference with general population. The incidence of NAFLD raised with the quartiles of TC, TG and LDL-C raising, while decreased with the HDL-Cā€² quartiles raising. After controlling confounding factors, TC and TC/HD-C had a positive relationship with NAFLD, while HDL-C had the opposite. Finally, the ROC analysis showed the area under the curve (AUC) of TC/HDL-C (0.645) was greater than TC (0.554), HDL-C (0.627) and Apolipoprotein B to Apolipoprotein A1 (ApoB/ApoA1) (0.613). The TC/HDL-C ratio has significant predictive value to NAFLD. The online version of this article (10.1186/s12944-019-0984-9) contains supplementary material, which is available to authorized users.
Article 0 Reads 0 Citations A propensity score matched comparison of readmissions and cost of laparoscopic cholecystectomy vs percutaneous cholecyst... Matthew M. Fleming, Michael P. Dewane, Jiajun Luo, Fangfang ... Published: 01 January 2019
The American Journal of Surgery, doi: 10.1016/j.amjsurg.2018.10.047
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Article 0 Reads 1 Citation A case-control study of exposure to organophosphate flame retardants and risk of thyroid cancer in women Nicole C. DeZiel, Huangdi Yi, Heather M. Stapleton, Huang Hu... Published: 05 June 2018
BMC Cancer, doi: 10.1186/s12885-018-4553-9
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Growing evidence demonstrates that exposure to organophosphate flame retardants (PFRs) is widespread and that these chemicals can alter thyroid hormone regulation and function. We investigated the relationship between PFR exposure and thyroid cancer and whether individual or temporal factors predict PFR exposure. We analyzed interview data and spot urine samples collected in 2010ā€“2013 from 100 incident female, papillary thyroid cancer cases and 100 female controls of a Connecticut-based thyroid cancer case-control study. We measured urinary concentrations of six PFR metabolites with mass spectrometry. We estimated odds ratios (OR) and 95% confidence intervals (95% CI) for continuous and categories (low, medium, high) of concentrations of individual and summed metabolites, adjusting for potential confounders. We examined relationships between concentrations of PFR metabolites and individual characteristics (age, smoking status, alcohol consumption, body mass index [BMI], income, education) and temporal factors (season, year) using multiple linear regression analysis. No PFRs were significantly associated with papillary thyroid cancer risk. Results remained null when stratified by microcarcinomas (tumor diameter ā‰¤ 1 cm) and larger tumor sizes (> 1 cm). We observed higher urinary PFR concentrations with increasing BMI and in the summer season. Urinary PFR concentrations, measured at time of diagnosis, are not linked to increased risk of thyroid cancer. Investigations in a larger population or with repeated pre-diagnosis urinary biomarker measurements would provide additional insights into the relationship between PFR exposure and thyroid cancer risk. The online version of this article (10.1186/s12885-018-4553-9) contains supplementary material, which is available to authorized users.
Article 0 Reads 1 Citation TSH, Thyroid Hormone and PTC - Reply Huang Huang, Jennifer Rusiecki, Robert Udelsman, Yawei Zhang Published: 04 February 2018
Cancer Epidemiology Biomarkers & Prevention, doi: 10.1158/1055-9965.EPI-17-0806
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BOOK-CHAPTER 1 Read 0 Citations Alcohol Consumption and Risk of Thyroid Cancer: A Population Based Case-Control Study in Connecticut Huang Huang, Nan Zhao, Yingtai Chen, Nicole DeZiel, Min Dai,... Published: 01 January 2018
Advances in Experimental Medicine and Biology, doi: 10.1007/978-3-319-98788-0_1
DOI See at publisher website
Article 1 Read 0 Citations Germline variants in DNA repair genes, diagnostic radiation and risk of thyroid cancer Jason E. Sandler, Huang Huang, Nan Zhao, Weiwei Wu, Fangfang... Published: 20 December 2017
Cancer Epidemiology Biomarkers & Prevention, doi: 10.1158/1055-9965.EPI-17-0319
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Radiation exposure is a well-documented risk factor for thyroid cancer; diagnostic imaging represents an increasing source of exposure. Germline variations in DNA repair genes could increase risk of developing thyroid cancer following diagnostic radiation exposure. No studies have directly tested for interaction between germline mutations and radiation exposure. Using data and DNA samples from a Connecticut population-based case-control study performed in 2010ā€“2011, we genotyped 440 cases of incident thyroid cancer and 465 population-based controls for 296 single-nucleotide polymorphisms (SNPs) in 52 DNA repair genes. We used multivariate unconditional logistic regression models to estimate associations between each SNP and thyroid cancer risk, as well as to directly estimate the genotype-environment interaction between each SNP and ionizing radiation. Three SNPs were associated with increased risk of thyroid cancer and with thyroid microcarcinoma: HUS rs2708896, HUS rs10951937, and MGMT rs12769288. No SNPs were associated with increased risk of larger tumor (>10mm) in the additive-model. The gene-environment interaction analysis yielded 24 SNPs with Pinteraction<0.05 for all thyroid cancer, 12 SNPs with Pinteraction<0.05 for thyroid microcarcinoma, and 5 SNPs with Pinteraction<0.05 for larger tumor. Germline variants in DNA repair genes are associated with thyroid cancer risk, and are differentially associated with thyroid microcarcinoma and large tumor size. Our study provides the first evidence that germline genetic variations modify the association between diagnostic radiation and thyroid cancer risk. Thyroid microcarcinoma may represent a distinct subset of thyroid cancer. The effect of diagnostic radiation on thyroid cancer risk varies by germline polymorphism.
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