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Raúl González-Domínguez     Post Doctoral Researcher 
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Raúl González-Domínguez published an article in September 2018.
Research Keywords & Expertise See all
0 A
0 Aluminum
0 Alzheimer's Disease
0 Cancer
0 Diabetes
0 Gas Chromatography
Top co-authors See all
Jose Luis Gómez-Ariza

197 shared publications

Department of Chemistry, Faculty of Experimental Sciences, University of Huelva, Campus de El Carmen, Huelva, Spain

Tamara García-Barrera

89 shared publications

Department of Chemistry, Faculty of Experimental Sciences; University of Huelva; Huelva Spain

Javier Vitorica

55 shared publications

Universidad de Sevilla

Ana Sayago

30 shared publications

Department of Chemistry, Faculty of Experimental Sciences, University of Huelva, 21007 Huelva, Spain

Juan Urbano

19 shared publications

Laboratorio de Catálisis Homogénea; Unidad Asociada al CSIC; CIQSO-Centro de Investigación en Química Sostenible and Departamento de Química; Universidad de Huelva; Campus de El Carmen 21007 Huelva Spain

40
Publications
91
Reads
8
Downloads
174
Citations
Publication Record
Distribution of Articles published per year 
(2012 - 2018)
Total number of journals
published in
 
26
 
Publications See all
Article 0 Reads 0 Citations Combination of complementary data mining methods for geographical characterization of extra virgin olive oils based on m... Ana Sayago, Raúl González-Domínguez, Rafael Beltrán, Ángeles... Published: 01 September 2018
Food Chemistry, doi: 10.1016/j.foodchem.2018.04.019
DOI See at publisher website
Article 0 Reads 7 Citations Metabolomics in Alzheimer’s disease: The need of complementary analytical platforms for the identification of biomarkers... Raúl González-Domínguez, Ana Sayago, Ángeles Fernández-Recam... Published: 01 December 2017
Journal of Chromatography B, doi: 10.1016/j.jchromb.2017.02.008
DOI See at publisher website PubMed View at PubMed
Article 3 Reads 1 Citation Application of Targeted Metabolomics to Investigate Optimum Growing Conditions to Enhance Bioactive Content of Strawberr... Ikram Akhatou, Ana Sayago, Raúl González-Domínguez, Ángeles ... Published: 20 October 2017
Journal of Agricultural and Food Chemistry, doi: 10.1021/acs.jafc.7b03701
DOI See at publisher website PubMed View at PubMed
Article 4 Reads 0 Citations Correction to: Metabolomic Fingerprinting of Blood Samples by Direct Infusion Mass Spectrometry: Application in Alzheime... Raúl González-Domínguez Published: 01 July 2017
Journal of Analysis and Testing, doi: 10.1007/s41664-017-0041-5
DOI See at publisher website
Article 0 Reads 1 Citation Synergic effects of sugar and caffeine on insulin-mediated metabolomic alterations after an acute consumption of soft dr... Raúl González-Domínguez, Rosa María Mateos, Alfonso María Le... Published: 22 May 2017
ELECTROPHORESIS, doi: 10.1002/elps.201700044
DOI See at publisher website PubMed View at PubMed
BOOK-CHAPTER 0 Reads 1 Citation Size Fractionation of Metal Species from Serum Samples for Studying Element Biodistribution in Alzheimer’s Disease Raúl González-Domínguez Published: 06 April 2017
Metals in the Brain, doi: 10.1007/978-1-4939-6918-0_8
DOI See at publisher website
Conference papers
CONFERENCE-ARTICLE 12 Reads 0 Citations Comparison of the metabolomic signature of diabetes and the oral glucose tolerance test Álvaro González-Domínguez, Alfonso Lechuga-Sancho, Raúl Gonz... Published: 31 October 2018
doi: 10.3390/ecmc-4-05571
DOI See at publisher website ABS Show/hide abstract

Intervention trials attempt to clarify the possible effects of certain challenge tests on study subjects (e.g. drugs effectiveness, environmental exposure experiments), while observational studies employ free-living populations to analyze the relationship between a particular effect and possible triggering factors. Based on the hypothesis under investigation, the researcher will choose the appropriate study design. Nevertheless, here we report the utility of combining observational and interventional studies to discover confident biomarkers in the clinical field (1). We contrasted metabolomic profiles related with diabetes and the oral glucose tolerance test (OGTT), a clinical test used to simulate the hyperinsulinemia observed in diabetes. We found that the main metabolic changes occur in the same metabolite classes, including energy-related metabolites, amino acids (especially brain chain amino acids, BCAA) and multiple lipids, such as free fatty acids, acyl-carnitines, triglycerides and phospholipids, among them. Hence, challenge tests such as the OGTT guarantee to be a great strategy to investigate pathological signatures associated with the development of diseases as a previous step before performing validation works in observational studies.

(1) Á. González-Domínguez, A.M. Lechuga-Sancho, R. González-Domínguez. Intervention and Observational Trials are Complementary in Metabolomics: Diabetes and the Oral Glucose Tolerance Test. Curr. Top. Med. Chem. 18 (2018) 896-900

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