Please login first
Mark Viant   Professor  Senior Scientist or Principal Investigator 
Timeline See timeline
Mark Viant published an article in December 2018.
Top co-authors See all
Roy Goodacre

327 shared publications

School of Chemistry, Manchester Institute for Biotechnology, University of Manchester, Manchester, UK

Philip J. Marriott

310 shared publications

Australian Centre for Research on Separation Science, School of Chemistry, Monash University, Melbourne, Australia

Oliver Fiehn

265 shared publications

Genome Center, University of California, Davis

Kazuki Saito

262 shared publications

Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8675, Japan

Joachim Kopka

180 shared publications

Applied Metabolome Analysis, Max-Planck-Institute for Molecular Plant Physiology, Am Mühlenberg 1, 14476 Potsdam-Golm, Germany

158
Publications
4
Reads
0
Downloads
1195
Citations
Publication Record
Distribution of Articles published per year 
(1996 - 2018)
Total number of journals
published in
 
31
 
Publications See all
Article 1 Read 0 Citations PhenoMeNal: Processing and analysis of Metabolomics data in the Cloud Kristian Peters, James Bradbury, Sven Bergmann, Marco Capucc... Published: 07 December 2018
GigaScience, doi: 10.1093/gigascience/giy149
DOI See at publisher website
Article 0 Reads 0 Citations Miniaturising acute toxicity and feeding rate measurements in Daphnia magna Konstantinos Grintzalis, Wenkui Dai, Konstantinos Panagiotid... Published: 01 May 2017
Ecotoxicology and Environmental Safety, doi: 10.1016/j.ecoenv.2017.02.002
DOI See at publisher website PubMed View at PubMed
Article 1 Read 2 Citations Defining the Baseline and Oxidant Perturbed Lipidomic Profiles of Daphnia magna. Nadine S Taylor, Thomas A White, Mark R Viant Published: 15 March 2017
Metabolites, doi: 10.3390/metabo7010011
DOI See at publisher website PubMed View at PubMed ABS Show/hide abstract
Recent technological advancement has enabled the emergence of lipidomics as an important tool for assessing molecular stress, one which has yet to be assessed fully as an approach in an environmental toxicological context. Here we have applied a high-resolution, non-targeted, nanoelectrospray ionisation (nESI) direct infusion mass spectrometry (DIMS) technique to assess the effects of oxidative stress to Daphnia magna both in vitro (air exposure of daphniid extracts) and in vivo (Cu2+ exposure). Multivariate and univariate statistical analyses were used to distinguish any perturbations including oxidation to the D. magna baseline lipidome. This approach enabled the putative annotation of the baseline lipidome of D. magna with 65% of the lipid species discovered previously not reported. In vitro exposure of lipid extracts to air, primarily to test the methodology, revealed a significant perturbation to this baseline lipidome with detectable oxidation of peaks, in most cases attributed to single oxygen addition. Exposure of D. magna to Cu2+ in vivo also caused a significant perturbation to the lipidome at an environmentally relevant concentration of 20 µg/L. This nESI DIMS approach has successfully identified perturbations and oxidative modifications to the D. magna lipidome in a high-throughput manner, highlighting its suitability for environmental lipidomic studies.
Article 1 Read 1 Citation Application of Passive Sampling to Characterise the Fish Exometabolome Mark R. Viant, Jessica Elphinstone Davis, Cathleen Duffy, Ja... Published: 14 February 2017
Metabolites, doi: 10.3390/metabo7010008
DOI See at publisher website ABS Show/hide abstract
The endogenous metabolites excreted by organisms into their surrounding environment, termed the exometabolome, are important for many processes including chemical communication. In fish biology, such metabolites are also known to be informative markers of physiological status. While metabolomics is increasingly used to investigate the endogenous biochemistry of organisms, no non-targeted studies of the metabolic complexity of fish exometabolomes have been reported to date. In environmental chemistry, Chemcatcher® (Portsmouth, UK) passive samplers have been developed to sample for micro-pollutants in water. Given the importance of the fish exometabolome, we sought to evaluate the capability of Chemcatcher® samplers to capture a broad spectrum of endogenous metabolites excreted by fish and to measure these using non-targeted direct infusion mass spectrometry metabolomics. The capabilities of C18 and styrene divinylbenzene reversed-phase sulfonated (SDB-RPS) Empore™ disks for capturing non-polar and polar metabolites, respectively, were compared. Furthermore, we investigated real, complex metabolite mixtures excreted from two model fish species, rainbow trout (Oncorhynchus mykiss) and three-spined stickleback (Gasterosteus aculeatus). In total, 344 biological samples and 28 QC samples were analysed, revealing 646 and 215 m/z peaks from trout and stickleback, respectively. The measured exometabolomes were principally affected by the type of Empore™ (Hemel Hempstead, UK) disk and also by the sampling time. Many peaks were putatively annotated, including several bile acids (e.g., chenodeoxycholate, taurocholate, glycocholate, glycolithocholate, glycochenodeoxycholate, glycodeoxycholate). Collectively these observations show the ability of Chemcatcher® passive samplers to capture endogenous metabolites excreted from fish.
Article 0 Reads 14 Citations Computational tools and workflows in metabolomics: An international survey highlights the opportunity for harmonisation ... Ralf J. M. Weber, Thomas N. Lawson, Reza M. Salek, Timothy M... Published: 27 December 2016
Metabolomics, doi: 10.1007/s11306-016-1147-x
DOI See at publisher website
Article 0 Reads 1 Citation Mass Spectrometry Based Metabolomics Comparison of Liver Grafts from Donors after Circulatory Death (DCD) and Donors aft... Olga Hrydziuszko, M. Thamara P. R. Perera, Richard Laing, Je... Published: 11 November 2016
PLOS ONE, doi: 10.1371/journal.pone.0165884
DOI See at publisher website PubMed View at PubMed ABS Show/hide abstract
Use of marginal liver grafts, especially those from donors after circulatory death (DCD), has been considered as a solution to organ shortage. Inferior outcomes have been attributed to donor warm ischaemic damage in these DCD organs. Here we sought to profile the metabolic mechanisms underpinning donor warm ischaemia. Non-targeted Fourier transform ion cyclotron resonance (FT-ICR) mass spectrometry metabolomics was applied to biopsies of liver grafts from donors after brain death (DBD; n = 27) and DCD (n = 10), both during static cold storage (T1) as well as post-reperfusion (T2). Furthermore 6 biopsies from DBD donors prior to the organ donation (T0) were also profiled. Considering DBD and DCD together, significant metabolic differences were discovered between T1 and T2 (688 peaks) that were primarily related to amino acid metabolism, meanwhile T0 biopsies grouped together with T2, denoting the distinctively different metabolic activity of the perfused state. Major metabolic differences were discovered between DCD and DBD during cold-phase (T1) primarily related to glucose, tryptophan and kynurenine metabolism, and in the post-reperfusion phase (T2) related to amino acid and glutathione metabolism. We propose tryptophan/kynurenine and S-adenosylmethionine as possible biomarkers for the previously established higher graft failure of DCD livers, and conclude that the associated pathways should be targeted in more exhaustive and quantitative investigations.
Top